TESTOLONE (RAD-140) – Solution, 600mg (20mg/mL)

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TESTOLONE (RAD-140)

RAD 140 Effects on Animal Body Mass

RAD 140 SARM, or (2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile, also known as testolone was originally synthesized for Radius Health Inc. in conjunction with researchers from the University of Illinois, Obiter Research, and Cambridge Major Laboratories.

Per the initial paper detailing the synthesis and preliminary findings of the compound, RAD140 has the stability to (t1/2 >2 h)  in incubations with rat and monkey microsomes, as well as a high affinity for the androgen receptor (Ki = 7 nM), approximately 4 times the affinity than that of testosterone itself. At the same time, the nearest hormone receptor activated by RAD140 was progesterone at a level of 750nM.

The earliest primate studies on RAD-140 indicated that even at the lowest dose range 0.1mg/kg, juvenile macaques gained a mean of ten percent in body weight, during the 28-day trial period, which was primarily confirmed to be lean body mass via DEXA scans performed before and after the trial period, however, this was somewhat variable.

 

RAD 140 Effects on Neurons

In a study conducted by Jayaraman et. Al, gonadectomized, male rats were studied to see the effects supplementation with RAD 140 had in regards to neuroprotection in order to make conclusions regarding the usefulness of SARMs against neurodegenerative disorders.

The rats were orally provided with 1 mg/kg a day of RAD 140 for 2 weeks. It was found that RAD140 was able to reduce apoptosis caused by Aᵝ, apoptosis activator II, and hydrogen peroxide by a significant amount. This is due to the role MAPK signaling plays in neuroprotection.

Aᵝ was by far the most potent of the apoptosis insults introduced to the rats. After 24 hours of exposure to Aᵝ, 50% of viable neurons in the rats had decreased, however, when given RAD 140 in a concentration-dependent matter, the viability of the neurons had increased exponentially. The most effective concentration of RAD 140 was 100 nM, which led to approximately 90% neuron survival after Aᵝ exposure (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/).

In addition to measuring the neuroprotection against various apoptosis insults, researchers also measured the effects RAD 140 had on kainate-induced neuron death. It was found that when compared to treatment with a vehicle, kainate-induced neuron death was significantly reduced (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/).

Concentration

20mg/ml.

Half Life

16 hours.

DISCLAIMER

This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary or domestic use. Please familiarize yourself with our DISCLAIMER before ordering.

 

Data Sheet

RAD140 (Testolone) – Solution, 600mg (20mg/mL)

Application Selective Androgen Receptor Modulator
CAS 1182367-47-0
Molar Mass 393.83 g/mol
 Chemical Formula C20H16ClN5O2
IUPAC Name 2-chloro-4-{[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino}-3-methylbenzonitrile
Synonyms RAD140, RAD-140, Testolone
Storage Room temperature
Solubility Soluble in Ethanol, PEG400
Organoleptic Profile Clear Liquid
Physical Form Solution in PEG400
Specification 20mg/mL ±5%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.

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