STENABOLIC (SR-9009)

SR9009, also known as Stenabolic, has been studied in mice and shown to increase running speed, reduce obesity levels, and boost mitochondrial production, thus enhancing muscle mass and metabolism.

Although SR-9009 is often associated with Selective Androgen Receptor Modulators (SARMs), it functions via different pathways. It is actually a Rev-ErbA agonist—a nuclear receptor reverse viral erythroblastosis oncogene product alpha agonist—found in the liver, skeletal muscles, and brain. It is most notable for its role in influencing circadian rhythms.

SR-9009 and Weight Loss

In a study conducted by Solt et al., mice were administered SR-9009 or saline injections twice a day while on a high-fat diet (comprising 60% fat and 20% carbohydrates). The study aimed to assess whether SR-9009 could aid weight loss in diet-induced obesity cases (source).

It was observed that due to the stress of bi-daily injections, both sets of mice lost body fat. However, mice treated with SR-9009 lost 60% more fat than those treated with saline injections. Additionally, substantial reductions were reported in plasma triglycerides (12%), total cholesterol (47%), plasma glucose levels (19%), leptin (80%), and inflammatory cytokines (72%) in the mice administered SR-9009 (source).

SR-9009 and Bone Density

In another intriguing study by Song et al., 12-week-old female mice were housed in a research laboratory under a strict 12-hour light and dark cycle and were provided with free access to food and water. Forty mice were divided into groups that either underwent full ovariectomy or a sham operation. After the procedure, the mice were injected with varying doses of SR-9009 (source).

Overall, the study's findings indicated that SR-9009 supplementation inhibited the differentiation of osteoclast formation in mice, suggesting reduced bone degradation. Furthermore, in female mice that underwent ovariectomy to simulate postmenopausal bone loss, supplementation with SR-9009 led to a greater number of bone trabeculae in the femur and tibia. The bone volume and tissue also increased by a factor of 1.550, 1.701, or 1.601 upon administering doses of 30, 50, or 100 mg/kg of SR-9009, respectively (source).

Concentration
20mg/ml.

Half Life
2.5 hours.

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Data Sheet

Stenabolic SR-9009 – Solution, 600mg (20mg/mL)