TESTOLONE (RAD-140)

RAD 140 Effects on Animal Body Mass

RAD 140 SARM, chemically known as (2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile), also known as testolone, was originally synthesized by Radius Health Inc. in collaboration with researchers from the University of Illinois, Obiter Research, and Cambridge Major Laboratories.

According to the initial study detailing the synthesis and preliminary findings of the compound, RAD140 exhibits high stability (with a half-life of more than 2 hours) in incubations with rat and monkey microsomes. It also has a high affinity for the androgen receptor, with a Ki of 7 nM, approximately four times higher than that of testosterone itself. Simultaneously, the nearest hormone receptor activated by RAD140 was progesterone, at a level of 750 nM.

Early primate studies indicated that even at the lowest dose of 0.1 mg/kg, juvenile macaques gained an average of 10% body weight over a trial period of 28 days. This increase was primarily confirmed to be lean body mass, as indicated by DEXA scans conducted before and after the trial period. These results were, however, somewhat variable.

RAD 140 Effects on Neurons

In a study conducted by Jayaraman et al., castrated male rats were investigated to determine the neuroprotective effects of RAD 140 supplementation, with a view towards potential applications of SARMs against neurodegenerative diseases.

The rats were orally provided with 1 mg/kg of RAD 140 per day for two weeks. It was found that RAD140 was able to significantly reduce apoptosis caused by Aβ, apoptosis activator II, and hydrogen peroxide. This is attributed to the role that MAPK signaling plays in neuroprotection.

Aβ was by far the most potent trigger of apoptosis introduced to the rats. After 24 hours of exposure to Aβ, the number of viable neurons in the rats had decreased by 50%. However, when administered RAD 140 in a concentration-dependent manner, the viability of the neurons increased exponentially. The most effective concentration of RAD 140 was 100 nM, leading to approximately 90% neuron survival after Aβ exposure (Source).

In addition to measuring the neuroprotective effects against various forms of apoptosis, researchers also measured the effects RAD 140 had on kainate-induced neuron death. It was found that this form of neuron death was significantly reduced compared to a control group (Source).

Concentration
20mg/ml.

Half Life
16 hours.

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Data Sheet

RAD140 (Testolone) – Solution, 600mg (20mg/mL)